Infective endocarditis is a common clinical problem in industrialized countries.Risk factors include abnormal cardiac valves, a history of endocarditis, intracardiac devices, prosthetic valves 3 Seater Sofa and intravenous drug use.We report a case of polymicrobial infective endocarditis in a 33 year-old female with a history chronic heroin use caused by Neisseria sicca and Haemophilus parainfluenzae.We believe the patient was Shoulder Tote Bag exposed to these microbes by cleansing her skin with saliva prior to injection.Pairing a detailed history with the consideration of atypical agents is crucial in the proper diagnosis and management of endocarditis in patients with high-risk injection behaviors.